Powerful new microscope puts UD at forefront in biomedical imaging
Dec. 13, 2010—-The University of Delaware is now one of only a handful of universities with a microscope so powerful that researchers can measure a single molecule within a cell.
The instrument, a Zeiss LSM780 laser-scanning confocal microscope recently installed in 304 Wolf Hall, was purchased through a $496,000 competitive grant awarded to UD from the National Institutes of Health (NIH) and an additional $65,000 from the Department of Biological Sciences.
Kirk Czymmek, director of UD’s Bio-imaging Core Center, and Melinda Duncan, professor of biological sciences, with the new state-of-the-art confocal microscope in 304 Wolf Hall.
Confocal microscopes allow scientists to visualize the inner workings of cells and tissues with spectacular clarity. UD’s new microscope will aid biomedical researchers at the University in making discoveries relevant to the development of cardiovascular disease, cataracts, osteoporosis, arthritis and cancer, as well as contribute to the development of biomaterials for repairing or replacing damaged tissues.
The state-of-the-art microscope not only can track the movement of molecules at very high speed, but it also can measure very large objects such as an entire eye, says Duncan, who does research on cataracts.
“The experiments we can do now are as good as, or better than, those of our peers. There are questions we can answer now that we never could before,” Duncan notes.
Among the coolest things Duncan’s been able to see for the first time, thanks to the new research tool, are the ball and sockets found on the outside of lens fiber cells. Previously, these structures were only viewable with an electron microscope, which limited possible research studies of their function.
Another colleague, Liyun Wang, assistant professor of mechanical engineering, is examining how fluids diffuse through bone in her research to develop efficient drug delivery systems to treat osteoporosis and arthritis.
“For the first time, we can measure these things,” Duncan says. “And our productivity is much higher because we can collect and save the data much faster with a device that has modern lasers, computers and electronics compared to our old microscope. While the old instrument did contribute data that allowed UD researchers to publish over 115 scientific papers, it was over a decade old and it was a struggle to keep it breathing,” she says wryly.
The new microscope will help advance the research of 10 priority users at UD, currently funded by NIH for studies ranging from tissue engineering to breast cancer metastasis. Other researchers also may reserve the instrument’s use when time is available.
“We want people to know that it’s here,” Czymmek says of the new microscope, which is primarily focused on health science topics. “Not only is the new microscope 10 times more sensitive than our other confocal microscopes, it adds new capabilities to our campus for measuring molecular dynamics in cells and materials using image correlation spectroscopy, fluorescence correlation spectroscopy and fluorescence polarization techniques.
“Now we need to replace our two other outdated confocal microscopes, which are rapidly becoming obsolete,” he adds. “We’re seeking partners and mechanisms to help make that happen and to further support our environmental, engineering and agricultural research at UD.”
For more information visit the DBI Bio-Imaging Center website or contact Czymmek at [email@example.com ].
https://microscopy-news.com/wp-content/uploads/2017/01/516b76019f18322d8d3a9ddc96987741.jpg300350Ottermediahttps://microscopy-news.com/wp-content/uploads/2017/01/Microscopy-news_logo_microscope_news.pngOttermedia2017-01-17 10:44:242017-01-17 10:44:24Andor launches KOMET 7 – The most advanced and powerful software solution for analysis, data management and presentation of comet assay samples
https://microscopy-news.com/wp-content/uploads/2017/01/543ba9c56fe57e856dc7f252e2ebd3ba.jpg466350Ottermediahttps://microscopy-news.com/wp-content/uploads/2017/01/Microscopy-news_logo_microscope_news.pngOttermedia2017-01-17 10:43:462017-01-17 10:43:46Advanced Thin Films Enters Medical Laser Optics Market
https://microscopy-news.com/wp-content/uploads/2017/01/7423894303b540804bd4b9ded95ac7a1.jpg228350otmarohttps://microscopy-news.com/wp-content/uploads/2017/01/Microscopy-news_logo_microscope_news.pngotmaro2017-01-17 10:43:332017-01-17 10:43:33Module transforms Raman microscopes into high throughput chemical analyzers
https://microscopy-news.com/wp-content/uploads/2017/01/ca9ed333736eb38ce4abbffcee37be60.jpg260350otmarohttps://microscopy-news.com/wp-content/uploads/2017/01/Microscopy-news_logo_microscope_news.pngotmaro2017-01-17 10:42:462017-01-17 10:42:46Motic Microscopes launches the new BA410E for biomedical applications
https://microscopy-news.com/wp-content/uploads/2017/01/2ed54dfbb5613dc8894327c8185309c1.jpg175350Ottermediahttps://microscopy-news.com/wp-content/uploads/2017/01/Microscopy-news_logo_microscope_news.pngOttermedia2017-01-17 10:42:442017-01-17 10:42:44R&D 100 Award 2014 for ZEISS ELYRA P.1 with 3D-PALM
https://microscopy-news.com/wp-content/uploads/2017/01/944a198042025732e6e8fb5a715d48c5.jpg243350otmarohttps://microscopy-news.com/wp-content/uploads/2017/01/Microscopy-news_logo_microscope_news.pngotmaro2017-01-17 10:41:572017-01-17 10:41:57Motic Microscopes presents the new AE31E for microbiology
https://microscopy-news.com/wp-content/uploads/2017/01/3725b94ba62d8e2205f5f20b3cdee1ee.jpg463350Ottermediahttps://microscopy-news.com/wp-content/uploads/2017/01/Microscopy-news_logo_microscope_news.pngOttermedia2017-01-17 10:41:372017-01-17 10:41:37CRAIC Technologies Website: A Resource for UV-Visible-NIR and Raman Microspectroscopy
https://microscopy-news.com/wp-content/uploads/2017/01/1affabb625a5c37519bafa89fedc162e.jpg86350otmarohttps://microscopy-news.com/wp-content/uploads/2017/01/Microscopy-news_logo_microscope_news.pngotmaro2017-01-17 10:41:102017-01-17 10:41:10Imaging companies in Europe shoulder-to-shoulder with life scientists
https://microscopy-news.com/wp-content/uploads/2017/01/341633931c01418c4fa8e0a90a8236d4.jpg139350otmarohttps://microscopy-news.com/wp-content/uploads/2017/01/Microscopy-news_logo_microscope_news.pngotmaro2017-01-17 10:39:052017-01-17 10:39:05XIMEA unveils Thunderbolt™ 2 high speed cameras with IMX174 and CMV20000
https://microscopy-news.com/wp-content/uploads/2017/01/22b06d4094468fc910406cd44d96ec1f.jpg181350Ottermediahttps://microscopy-news.com/wp-content/uploads/2017/01/Microscopy-news_logo_microscope_news.pngOttermedia2017-01-17 10:37:192017-01-17 10:37:19Dolomite´s new microfluidic system showcases droplet merging at nanoliter sample scale
https://microscopy-news.com/wp-content/uploads/2017/01/a5d0c77f7619812a129b2a4e6a9cb90b.jpg234350otmarohttps://microscopy-news.com/wp-content/uploads/2017/01/Microscopy-news_logo_microscope_news.pngotmaro2017-01-17 10:36:522017-01-17 10:36:52Point Grey´s Latest Blackfly® GigE PoE Camera Features Popular High Sensitivity VGA CCD
https://microscopy-news.com/wp-content/uploads/2017/01/a77db128b10a613c26b9e4dbea5dae02.jpg220350Ottermediahttps://microscopy-news.com/wp-content/uploads/2017/01/Microscopy-news_logo_microscope_news.pngOttermedia2017-01-17 10:36:392017-01-17 10:36:39Point Grey Launches New Grasshopper®3 Family of High Resolution GigE Vision™ PoE Cameras