Applied Visual Sciences Launches TBDxV™ TB Diagnostic Aid in India

HERNDON, Va. — April 25, 2011 — Signature Mapping Medical Sciences, the healthcare subsidiary of Applied Visual Sciences, Inc. (OTCBB: APVS – News), has begun TBDxV™ product sales and marketing initiatives through its subsidiary and agents in India. TBDxV, a fully automated tuberculosis (TB) visualization technology to aid in the diagnosis of TB, addresses the approximately 52 million diagnostic slides analyzed by clinical lab technicians each year.

TBDxV provides automated computer-aided analysis for a clinician; specifically displaying acid-fast TB bacteria using Signature Mapping’s advanced computer vision and pattern recognition technologies. Its high-throughput 200-slide capacity automatically and continuously scans stained sputum slides from four removable slide magazines, providing quick display of the results and digitized images for diagnostic review. Additionally, the application provides a patient report that features patient information, TB load, and severity statistics.

TBDxV is targeted to government and private institutions that screen tuberculosis patients. It is the precursor to TBDx, a TB diagnostics system currently nearing completion of Phase II clinical trials in South Africa that features automatic TB detect ion capabilities.

“India processes more TB diagnostic slides than anywhere in the world and the workload has overwhelmed the country’s laboratory resources,” said Bill Donovan, Applied Visual Sciences President & COO, “TBDxV will greatly enhance the productivity of India’s TB sputum microscopy technicians by helping them more quickly locate and identify TB bacilli in slides. Our TB visualization system streamlines this tedious task and helps overcome the wide variations in slide quality and TB bacilli to enable technicians to improve diagnostic accuracy.”

Donovan added, “We are working closely with the Indian government regarding our TBDx diagnostic system and hope that we can further enhance their TB diagnostics productivity after clinical trials and other government clearances are received.”

How TBDxV works:
Signature Mapping TBDxV™ software integrates APVS’s patented visualization algorithms and processes with existing analog bright-field microscopes to highlight tuberculosis bacilli in sputum slides. The 200-slide capacity “auto-loader” delivers individual slides to a microscope slide stage. A digital camera is attached to the microscope and it captures and digitizes images of the Ziehl-Neelsen-stained sputum slide samples. These images are treated as digital “fields of view (FOV).” The images are then displayed on the workstation monitor. For each FOV, the technician will input the count of bacilli, establishing a “load” count for each specimen; accumulate and tally the data; and output a report on the findings including the current severity.

TBDxV features:
• Real-time image processing and a FOV Slide Manager to compensate for variations.
• Patient work list and identifiers.
• Digitizes (into DICOM) each slide by FOV and processes with Signature Mapping™ visualization software.
• Displays slide images, and presents visualizations of suspected areas of tuberculosis.
• Magnifies and manipulates slide images, and provides areas where the lab technician can annotate individual images, navigate, and manipulate digital slide images,
• Generates World Health Organization standard report results with manual data entry capabilities.
• Microsoft Windows based SQL Server Database for image storage using standard DICOM file-based storage mechanisms.

TBDxV provides several clinical workflow advantages:
1. Does not require oil immersion for TBDxV to operate effectively and efficiently;
2. Minimizes human error associated with slide preparation;
3. Improves detection accuracy and patient outcome;
4. Reduces human fatigue and improves staff productivity and,
5. Minimizes error associated with stain variation

Applied Visual Sciences, Inc.
Applied Visual Sciences, Inc. is the holding company and IT development organization for subsidiaries specializing in high-performance imaging analysis technologies and advanced analytics for automated recognition of targets of interest. Applied Visual Sciences’ subsidiaries are Guardian Technologies International, Inc., a homeland security/defense technology entity, and Signature Mapping Medical Sciences, Inc., a healthcare technology entity. The Company is publicly traded on Nasdaq as APVS.

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CONTACT:
For Applied Visual Sciences: Michael Trudnak +1 703-464-5495
For Public Relations: Julie Shepherd of Accentuate PR, +1 815-479-1833, Julie@accentuatePR.com

www.signaturemapping.com
www.appliedvs.com